Selected Data: Breast Cancer

 

Mouse Model of Human Breast Cancer: How Sphingomab™ Retards Tumor Growth and Tumor Viability

Graph A.

  • Human breast MDA MB 231 tumor cells (multi-drug-resistant)
  • Treatment does not begin until tumors have grown extremely large (~700mm3)

Conclusion:
Sphingomab™ significantly reduces tumor progression, even against well-established, multi-drug-resistant tumors

Graphs such as the one above do not reflect cell viability within the tumor, which can best be shown by PET scans:

Graph B.

Graphs such as the one above do not reflect cell viability within the tumor; such viability can be demonstrated by "staining" sections of the tumor through a method called H&E (see images below).

The tumor section from an untreated mouse, shown on the left, reflects viable tumor cells (viable cells take up the blue-colored stain), as well as large red-colored blood vessels associated with angiogenesis.

Compare this with the image on the right, which is a tumor section from a Sphingomab™- treated mouse. Note that just vestiges of blood vessels remain, and also note the substantial pink/gray (unstained) area, which reflects necrosis (cell death)...i.e., there are considerably fewer viable cells in the core of the tumor.